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Synthesis of 3-Deoxy-D-manno-2-octulosonic Acid (KDO)

✍ Scribed by Prof. Dr. Richard R. Schmidt; Rainer Betz


Publisher
John Wiley and Sons
Year
1984
Tongue
English
Weight
208 KB
Volume
23
Category
Article
ISSN
0044-8249

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πŸ“œ SIMILAR VOLUMES


A Silicon-Mediated Synthesis of 3-Deoxy-
✍ Nico BrΓ€uer; Andreas Kirschning; Ernst Schaumann πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 115 KB

KDO (1) is synthesized in five steps, starting from 1,2-to the carbonate 9. Silicon-induced lactonization affords the lactone 10, which can be converted into NH 4 -KDO by anhydro-3,4:5,6-di-O-isopropylidene-D-mannitol ( 6). The epoxide 6, obtained from D-mannitol (2), reacts with lithiated standard