A Silicon-Mediated Synthesis of 3-Deoxy-
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Nico BrΓ€uer; Andreas Kirschning; Ernst Schaumann
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Article
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1998
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John Wiley and Sons
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English
β 115 KB
KDO (1) is synthesized in five steps, starting from 1,2-to the carbonate 9. Silicon-induced lactonization affords the lactone 10, which can be converted into NH 4 -KDO by anhydro-3,4:5,6-di-O-isopropylidene-D-mannitol ( 6). The epoxide 6, obtained from D-mannitol (2), reacts with lithiated standard