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ChemInform Abstract: Synthesis and Evaluation of 3-Deoxy-D-manno-2-octulosonate-8-phosphate (KDO8P) Synthase Inhibitors.

โœ Scribed by H. LIU; W. LI; C. U. KIM


Publisher
John Wiley and Sons
Year
2010
Weight
33 KB
Volume
28
Category
Article
ISSN
0931-7597

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3-Deoxy-D-manm-octulosonate-8-phosphate (KDOP) synthase catalyzes the production of KDOP from phosphoenolpyruvate (PEP) and arabinose-5-phosphate (A5P). In gram-negative bacteria KDOP is subsequently dephosphorylated, cytidylylated, and linked to lipid A and is required for lipid A incorporation int