𝔖 Bobbio Scriptorium
✦   LIBER   ✦

A new synthesis for 2-deoxy-KDO, a potent inhibitor of CMP=KDO synthetase

✍ Scribed by Francisco Sarabia-García; Fidel J. López-Herrera; María S. Pino-González

Publisher
Elsevier Science
Year
1994
Tongue
French
Weight
295 KB
Volume
35
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

✦ Synopsis

A new synthesis for the 2-dcoxy KDO 2 by aldolic condmsation of 2,3:5,6diGi~ l-D-mmmo ald&yde. 4 with ethyl dituoacetate and cowersion of the cwdensation product to the f-dcoxyPdiam ester1Jinfourstepgisreponed.Rhodium(~decompositionofthediazocompoundleadsu,theu-enannaofthe 2dcoxy pyrawae 14 stereospecifically. Removal of isopmpylidene groups and es@ hydrolysis provides 2, a potent inhibitor of CMP-KDO synth~.

📜 SIMILAR VOLUMES

A new synthesis of 2-deoxy-β-Kdo, a pote
A new synthesis of 2-deoxy-β-Kdo, a potent CMP-Kdo synthetase inhibitor
✍ Hiroshi Ohrui; Masahiro Morita; Hiroshi Meguro 📂 Article 📅 1992 🏛 Elsevier Science 🌐 English ⚖ 495 KB

CMP-Kdo synthetase' catalyzes a key step in the biosynthesis of bacterial lipopolysaccharide'. Recently, the 2-deoxy derivative of/LKdo (7) was reported to be a potent inhibitor of CMP-Kdo synthetase3. Two different syntheses of 7 have been reported4v5, the first involving hydrogenolysis of the glyc

Synthesis of a new series of potent inhi
Synthesis of a new series of potent inhibitors of thromboxane A2 biosynthesis
✍ E.J. Corey; Stephen G. Pyne; Andrew I. Schafer 📂 Article 📅 1983 🏛 Elsevier Science 🌐 French ⚖ 206 KB

The pyridino prostanoids 2, 12 and lfl have been synthesized (in racemic form) and have been found to be effective inhibitors of the biosynthesis of thromboxane A2 in human platelets QC,, l-3 PM).