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Synthesis of Azabicycloalkane Amino Acid Scaffolds as Reverse-Turn Inducer Dipeptide Mimics

✍ Scribed by Mauro Angiolini; Silvia Araneo; Laura Belvisi; Edoardo Cesarotti; Anna Checchia; Luca Crippa; Leonardo Manzoni; Carlo Scolastico

Publisher: John Wiley and Sons
Year: 2000
Tongue: English
Weight: 410 KB
Volume: 2000
Category: Article
ISSN: 1434-193X
DOI: 10.1002/1099-0690(200007)2000:14<2571::aid-ejoc2571>3.0.co;2-d

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Conformational Analysis of Azabicycloalk

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In an effort to design structural mimics of protein and peptide reverse-turns, the conformations of 5,5-, 6,5-, and 7,5-fused 1-aza-2-oxobicycloalkane amino acids have been evaluated. The conformational preferences of these proline-derived bicyclic lactams have been studied by Monte Carlo molecular

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## Abstract For Abstract see ChemInform Abstract in Full Text.