In an effort to design structural mimics of protein and peptide reverse-turns, the conformations of 5,5-, 6,5-, and 7,5-fused 1-aza-2-oxobicycloalkane amino acids have been evaluated. The conformational preferences of these proline-derived bicyclic lactams have been studied by Monte Carlo molecular
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Design, Synthesis, Conformational Analysis and Application of Azabicycloalkane Amino Acids as Constrained Dipeptide Mimics
โ Scribed by Laura Belvisi; Lino Colombo; Leonardo Manzoni; Donatella Potenza; Carlo Scolastico
- Publisher
- John Wiley and Sons
- Year
- 2004
- Weight
- 10 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0931-7597
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Conformationally constrained amino acid and dipeptide units can serve in mimics of specific secondary structures for studying relationships between peptide conformation and biological activity. A variety of mimics are required to study systematically the structure-activity relationships in biologica