Conformational Analysis of Azabicycloalk
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Laura Belvisi; Anna Bernardi; Leonardo Manzoni; Donatella Potenza; Carlo Scolast
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Article
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2000
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John Wiley and Sons
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English
โ 312 KB
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In an effort to design structural mimics of protein and peptide reverse-turns, the conformations of 5,5-, 6,5-, and 7,5-fused 1-aza-2-oxobicycloalkane amino acids have been evaluated. The conformational preferences of these proline-derived bicyclic lactams have been studied by Monte Carlo molecular