## Abstract The synthesis of novel analogues of foric acid (FA) antagonists derived from the pyrazino[2,3‐c]‐1,2,6‐thiadiazine 2,2‐dioxide system incorporating the glutamic acid side chain at the 7‐position is described. No significant DHFR inhibition of cytotoxic activity has been found with these
Synthesis of analogues of 6?-bromopenicillanic acid and penicillanic acid S,S-dioxide. Part 1. Synthesis of 3?-derivatives of 6?-bromo-2,2-dimethylpenam and 2,2-dimethylpenam S,S-dioxide
✍ Scribed by Mata, Ernesto G.; Setti, Eduardo L.; Mascaretti, Oreste A.; Boggio, Silvans B.; Roveri, Oscar A.
- Book ID
- 126511062
- Publisher
- Royal Society of Chemistry
- Year
- 1988
- Weight
- 776 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1472-7781
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📜 SIMILAR VOLUMES
The tide compounds were prepared from key intermediates readily obtained by the stereoselective Diels-Alder reaction of (Z)-2-pbenyl-4-[(S)-2,2-dimethyl-l,3dioxolan-4-ylmethylene]-5(4H)-oxazolone, a chiral az-lactone derived from (R)glyceraldehyde and cyclopentadiene.
## Abstract For Abstract see ChemInform Abstract in Full Text.
## Abstract A series of 2‐substituted 2__H__‐thieno[3,4‐__e__][1,2,4]thiadiazin‐3(4__H__)‐one 1,1‐dioxides (**2**), 2‐substituted 2__H__‐thieno[2,3‐__e__][1,2,4]thiadiazin‐3(4__H__)‐one 1,1‐dioxides (**3**), 2‐substituted 4,6‐dihydropyrazolo[4,3‐__e__]‐[1,2,4]thiadiazin‐3(2__H__)‐one 1,1‐dioxides (