Synthesis of (2S,3S)-[3-2H1]-4-methyleneglutamic acid and (2S,3R)-[2,3-2H2]-4-methyleneglutamic acid
β Scribed by Dieterich, Petra; Young, Douglas W.
- Book ID
- 119950244
- Publisher
- Royal Society of Chemistry
- Year
- 2006
- Tongue
- English
- Weight
- 170 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1477-0520
- DOI
- 10.1039/b601098a
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Epoxy ring opening of 2 and 2 with [ l -1 4 C ] hexadecyl copper lo gave respectivezy t h e analog 4 of agaric acid trimethyl e s t e r and methy2 b -1 4 ~J a g a r i c a t e 5, which-was hydrolysed t o -& by Zithium hy-&oxide i n I, 2-dimethoxyethane (DME). Epoxy ring trans opening of -2 with d i
Both 2S,3R-[2,3-2H2]-serine 5 and 2S,3S-[3-2H]-serine 6 have been pre ared from (E)-methyl-[2,3-2H2]-acrylate and (Z)-ethyl-[3-qH]-acrylate, respectively. The acrylate esters were converted to a mixture of isomeric bromohydrins by treatment with N-bromoacetamide. The ratio of 2-bromo-3-hydroxy speci
The tide compounds were prepared from key intermediates readily obtained by the stereoselective Diels-Alder reaction of (Z)-2-pbenyl-4-[(S)-2,2-dimethyl-l,3dioxolan-4-ylmethylene]-5(4H)-oxazolone, a chiral az-lactone derived from (R)glyceraldehyde and cyclopentadiene.