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Synthesis of an analogue of D,L-MYO-inositol-1,2-cyclic phosphate: inhibition of phosphatidylinositol-specific phospholipase C

โœ Scribed by A. Stewart Campbell; Gregory R.J. Thatcher


Book ID
118549880
Publisher
Elsevier Science
Year
1991
Tongue
French
Weight
272 KB
Volume
32
Category
Article
ISSN
0040-4039

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A fluorescent water-soluble substrate for phosphatidylinositol-specific phospholipase C was synthesized. The diacylglycerol moiety of the natural substrate, phosphatidylinositol, was replaced by the fluorescent moiety, 2-naphthol, resulting in the synthetic substrate, racemic 2-naphthyl myo-inositol