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Synthesis of Amphotericin B. A Convergent Strategy to the Polyol Segment of the Heptaene Macrolide Antibiotics

โœ Scribed by McGarvey, Glenn J.; Mathys, Jeffrey A.; Wilson, Kenneth J.


Book ID
115449086
Publisher
American Chemical Society
Year
1996
Tongue
English
Weight
181 KB
Volume
61
Category
Article
ISSN
0022-3263

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ChemInform Abstract: Synthesis of Amphot
โœ G. J. MCGARVEY; J. A. MATHYS; K. J. WILSON ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 33 KB ๐Ÿ‘ 2 views

Synthesis of Amphotericin B, a Convergent Strategy to the Polyol Segment of the Heptaene Macrolide Antibiotics. -The key step in the synthesis of the ester (VIII), a potent precursor of amphotericin B, is stereoselective cycloaddition of the dipolarophile (III) to the nitrile oxide generated from t