ChemInform Abstract: Synthesis of Amphot
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G. J. MCGARVEY; J. A. MATHYS; K. J. WILSON
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Article
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2010
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John Wiley and Sons
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Synthesis of Amphotericin B, a Convergent Strategy to the Polyol Segment of the Heptaene Macrolide Antibiotics. -The key step in the synthesis of the ester (VIII), a potent precursor of amphotericin B, is stereoselective cycloaddition of the dipolarophile (III) to the nitrile oxide generated from t