ChemInform Abstract: Synthesis of 6-Deoxyerythronolide B. Implementation of a General Strategy for the Synthesis of Macrolide Antibiotics.
β Scribed by D. A. EVANS; A. S. KIM
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 36 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0931-7597
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Synthesis of Amphotericin B, a Convergent Strategy to the Polyol Segment of the Heptaene Macrolide Antibiotics. -The key step in the synthesis of the ester (VIII), a potent precursor of amphotericin B, is stereoselective cycloaddition of the dipolarophile (III) to the nitrile oxide generated from t