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ChemInform Abstract: Synthesis of Amphotericin B, a Convergent Strategy to the Polyol Segment of the Heptaene Macrolide Antibiotics.

✍ Scribed by G. J. MCGARVEY; J. A. MATHYS; K. J. WILSON

Publisher: John Wiley and Sons
Year: 2010
Weight: 33 KB
Volume: 28
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199703287

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✦ Synopsis

Synthesis of Amphotericin B, a Convergent Strategy to the Polyol Segment of the Heptaene Macrolide Antibiotics.

-The key step in the synthesis of the ester (VIII), a potent precursor of amphotericin B, is stereoselective cycloaddition of the dipolarophile (III) to the nitrile oxide generated from the oxime (IV). -(MCGARVEY, G.

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