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A first convergent synthesis of the polyolic fragment of the antifungal pentaene macrolide strevertene A

โœ Scribed by Carlo Bonini; Lucia Chiummiento; Maria Funicello; Paolo Lupattelli; Valeria Videtta


Book ID
104095594
Publisher
Elsevier Science
Year
2008
Tongue
French
Weight
442 KB
Volume
49
Category
Article
ISSN
0040-4039

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Synthesis of Amphotericin B, a Convergent Strategy to the Polyol Segment of the Heptaene Macrolide Antibiotics. -The key step in the synthesis of the ester (VIII), a potent precursor of amphotericin B, is stereoselective cycloaddition of the dipolarophile (III) to the nitrile oxide generated from t