𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of amphiphilic polyhydroxylated pyrrolidines as potential glycosidase inhibitors

✍ Scribed by Annamaria Esposito; Massimo Falorni; Maurizio Taddei

Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
229 KB
Volume
39
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

✦ Synopsis

Several polyhydroxylated pyrrolidines with an aliphatic long chain on the ring nitrogen were prepared starting from D-mannitol. An amphiphilic bis-azasugar scaffold has been also prepared. These products behave as cationic surfactants and show a promising anti HIV-1 activity.

📜 SIMILAR VOLUMES

Synthesis of Pyrrolidine-Based Imino Sug
Synthesis of Pyrrolidine-Based Imino Sugars as Glycosidase Inhibitors
✍ Venkata Ramana Doddi; Yashwant D. Vankar 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 206 KB 👁 1 views

## Abstract Two pyrrolidine‐based imino sugars have been synthesized in an efficient manner, using regiospecific amination, ring closing metathesis, and diastereospecific dihydroxylations as key steps. These azasugars are found to be moderate inhibitors of glycosidases. (© Wiley‐VCH Verlag GmbH & C

Polycyclitols: synthesis of novel carbas
Polycyclitols: synthesis of novel carbasugar and conduritol analogues as potential glycosidase inhibitors
✍ Goverdhan Mehta; Senaiar S Ramesh 📂 Article 📅 2001 🏛 Elsevier Science 🌐 French ⚖ 86 KB

Stereoselective syntheses of a new family of hydrindane based bicyclitols with seven hydroxyl groups in a diverse stereochemical array have been accomplished from readily available building-blocks. One of the bicyclitols 12 has been found to exhibit moderate a-glucosidase inhibitory activity in enzy

Synthesis of Hybrids of D-Glucose and D-
Synthesis of Hybrids of D-Glucose and D-Galactose with Pyrrolidine-Based Iminosugars as Glycosidase Inhibitors
✍ Venkata Ramana Doddi; Hari Prasad Kokatla; A. P. John Pal; Ranjan K. Basak; Yash 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 250 KB 👁 1 views

## Abstract Sugar–iminosugar hybrid molecules made up of D‐glucose and D‐galactose with pyrrolidine‐based iminosugars, viz. 1,4‐dideoxy‐1,4‐imino‐L‐xylitol and 1,4‐dideoxy‐1,4‐imino‐L‐lyxitol, are synthesized from glycal epoxides and found to be moderate glycosidase inhibitors. (© Wiley‐VCH Verlag