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Polycyclitols: synthesis of novel carbasugar and conduritol analogues as potential glycosidase inhibitors

✍ Scribed by Goverdhan Mehta; Senaiar S Ramesh

Publisher: Elsevier Science
Year: 2001
Tongue: French
Weight: 86 KB
Volume: 42
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)00050-8

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✦ Synopsis

Stereoselective syntheses of a new family of hydrindane based bicyclitols with seven hydroxyl groups in a diverse stereochemical array have been accomplished from readily available building-blocks. One of the bicyclitols 12 has been found to exhibit moderate a-glucosidase inhibitory activity in enzymatic assays.

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