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Synthesis and Evaluation as Glycosidase Inhibitors of Carbasugar-Derived Spirodiaziridines, Spirodiazirines, and Spiroaziridines.

✍ Scribed by Peter Kapferer; Veronique Birault; Jean-Francois Poisson; Andrea Vasella

Publisher
John Wiley and Sons
Year
2003
Weight
182 KB
Volume
34
Category
Article
ISSN
0931-7597

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πŸ“œ SIMILAR VOLUMES

Synthesis and Evaluation as Glycosidase
Synthesis and Evaluation as Glycosidase Inhibitors of Carbasugar-Derived Spirodiaziridines, Spirodiazirines, and Spiroaziridines
✍ Peter Kapferer; VΓ©ronique Birault; Jean-FranΓ§ois Poisson; Andrea Vasella πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 German βš– 250 KB

## Dedicated to Professor Wolfgang Steglich on the occasion of his 70th birthday The spirodiaziridines 6 and 9, potential inhibitors of aand b-glucosidases, were prepared from the validoxylamine A-derived cyclohexanone 5. The trimethylsilyl protecting groups of 5 are crucial for the formation of 6

Synthesis of N-Acetylglucosamine-Derived
Synthesis of N-Acetylglucosamine-Derived Nagstatin Analogues and Their Evaluation as Glycosidase Inhibitors
✍ Miroslav Terinek; Andrea Vasella πŸ“‚ Article πŸ“… 2005 πŸ› John Wiley and Sons 🌐 German βš– 154 KB

## Abstract The __gluco__‐configured analogue **15** of nagstatin (**1**) and the methyl ester **14** were synthesized __via__ condensation of the thionolactams **17** or **18** with the __Ξ²__‐amino ester **19**. The silyl ethers **20** and **21** resulting from **17** were desilylated to **22** an