𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of Pyrrolidine-Based Imino Sugars as Glycosidase Inhibitors

✍ Scribed by Venkata Ramana Doddi; Yashwant D. Vankar

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
206 KB
Volume
2007
Category
Article
ISSN
1434-193X

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Two pyrrolidine‐based imino sugars have been synthesized in an efficient manner, using regiospecific amination, ring closing metathesis, and diastereospecific dihydroxylations as key steps. These azasugars are found to be moderate inhibitors of glycosidases. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)

📜 SIMILAR VOLUMES

Synthesis of Hybrids of D-Glucose and D-
Synthesis of Hybrids of D-Glucose and D-Galactose with Pyrrolidine-Based Iminosugars as Glycosidase Inhibitors
✍ Venkata Ramana Doddi; Hari Prasad Kokatla; A. P. John Pal; Ranjan K. Basak; Yash 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 250 KB

## Abstract Sugar–iminosugar hybrid molecules made up of D‐glucose and D‐galactose with pyrrolidine‐based iminosugars, viz. 1,4‐dideoxy‐1,4‐imino‐L‐xylitol and 1,4‐dideoxy‐1,4‐imino‐L‐lyxitol, are synthesized from glycal epoxides and found to be moderate glycosidase inhibitors. (© Wiley‐VCH Verlag