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Synthesis of amino alcohols on solid support via sulfonium-ion mediated Darzens reaction

โœ Scribed by Bernd Peschke; Joan Gredal Bundgaard; Jens Breinholt

Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
100 KB
Volume
42
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

Epoxides were synthesized on a solid support via an immobilized sulfonium salt, which is generated from a bromoacetic amide. Subsequent ring opening with amines leads to a single diastereoisomer of an amino alcohol, which can be cleaved from the solid support.

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