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Synthesis of 2-Oxindole Derivatives via the Intramolecular Heck Reaction on Solid Support

✍ Scribed by Vijayalaksmi Arumugam; Anne Routledge; Chris Abell; Shankar Balasubramanian

Publisher: Elsevier Science
Year: 1997
Tongue: French
Weight: 523 KB
Volume: 38
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(97)01481-0

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✦ Synopsis

Solid phase intramolecularHeck couplingallows the syothesisof 2-oxindoles. Additional diversityis introducedinfo the moleculeby reductiveatkylationprior to the Heck cyclisationarrdatso by conjugateadditionof a varietyof nucleophilesontothe cyctisedproductprior to cleavage. 01997 Elsevier ScienceLtd.

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