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Efficient Synthesis of Chiral Isoquinoline and Pyrido[1,2-b]-isoquinoline Derivatives via Intramolecular Heck Reactions

✍ Scribed by Francisco Sánchez-Sancho; Enrique Mann; Bernardo Herradón

Publisher: John Wiley and Sons
Year: 2001
Tongue: English
Weight: 149 KB
Volume: 343
Category: Article
ISSN: 1615-4150
DOI: 10.1002/1615-4169(20010430)343:4<360::aid-adsc360>3.0.co;2-2

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✦ Synopsis

The palladium(0)-catalyzed reaction of derivatives of g-amino-a,b-unsaturated esters bearing an N-(2-iodobenzoyl) substituent results in an intramolecular Heck reaction, the outcome of which depends on the structure of the substrate as well as on the experimental conditions. The methodology developed has been applied to the efficient syntheses of chiral isoquinoline and pyrido[1,2-b]isoquinoline derivatives.

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