2-Oxopiperazines containing up to five variable ring substituents can be obtained by the tandem SN2/Michael addition of amines to unsaturated peptoids on solid support.
The synthesis of 2-oxopiperazines by intramolecular Michael addition on solid support
โ Scribed by Dane A. Goff; Ronald N. Zuckermann
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- French
- Weight
- 215 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0040-4039
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๐ SIMILAR VOLUMES
Solid phase intramolecularHeck couplingallows the syothesisof 2-oxindoles. Additional diversityis introducedinfo the moleculeby reductiveatkylationprior to the Heck cyclisationarrdatso by conjugateadditionof a varietyof nucleophilesontothe cyctisedproductprior to cleavage. 01997 Elsevier ScienceLtd.
A novel route for the synthesis of tetrahydropyrazine-2-ones on solid support through intramolecular Mitsunobu reactions is reported. The syntheses employ reductive amination of commercially available amino alcohols to attach them to ArgoGeI-MB-CHO resin. Amino acids are then coupled to the derivati