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Synthesis of primary amines via nucleophilic addition of organometallic reagents to aldimines on solid support

✍ Scribed by Alan R. Katritzky; Linghong Xie; Guifen Zhang; Michael Griffith; Karen Watson; John S. Kiely


Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
189 KB
Volume
38
Category
Article
ISSN
0040-4039

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A series of a,a-disubstituted amines have been prepared in a simple and efficient one-pot procedure by the addition of Grignard reagents to a series of aliphatic, aromatic, and heteroaromatic nitriles. Key to this reported procedure is the unprecedented addition of the Grignard reagent to the nitril