The first asymmetric synthesis of the naturally occurring (+)-Kotanin is described. The key steps involve the intramolecular oxidative coupling of the cyanocuprate intermediate and the Fries rearrangement. The absolute configuration of (+)-Kotanin was assigned as aS by CD spectroscopic method. (~) 1
Synthesis of all the four possible stereoisomers of acaterin, naturally occurring ACAT inhibitor, and the determination of its absolute configuration
β Scribed by Ken Ishigami; Takeshi Kitahara
- Book ID
- 107857561
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- French
- Weight
- 874 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0040-4020
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The First Asymmetric Synthesis of the Naturally Occurring (+)-Kotanin and the Assignment of Its Absolute Configuration. -The key steps in the synthesis of the title compound (IX) are cyclization of the dibromide (II) and Fries rearrangement of the diacetate derived from the diol (IV). The absolute
Four stereoisomers of nodulisporacid A (1) were synthesized by the concise approach which includes three-component reaction and subsequent one-pot construction of the whole framework. The 1 H NMR comparison of the derivatives (10-12) revealed the absolute configuration of natural 1 to be 4R,4 0 R,6