Concise Synthesis of All Stereoisomers of β-Methoxytyrosine and Determination of the Absolute Configuration of the Residue in Callipeltin A
✍ Scribed by Zampella, Angela; D'Orsi, Rosa; Sepe, Valentina; Casapullo, Agostino; Monti, Maria Chiara; D'Auria, Maria Valeria
- Book ID
- 120994701
- Publisher
- American Chemical Society
- Year
- 2005
- Tongue
- English
- Weight
- 90 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1523-7060
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## Abstract The synthesis of 3,4‐didehydroionone isomers **4**, (+)‐**6**, and (−)‐**6** and of 3,4‐didehydro‐7,8‐dihydroionone isomers **5**, (+)‐**7**, and (−)‐**7** was accomplished starting from commercially available racemic __α__‐ionone (**1**). Their preparation of the racemic forms **4**–**
Four stereoisomers of nodulisporacid A (1) were synthesized by the concise approach which includes three-component reaction and subsequent one-pot construction of the whole framework. The 1 H NMR comparison of the derivatives (10-12) revealed the absolute configuration of natural 1 to be 4R,4 0 R,6