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Synthesis of aldose reductase inhibitor, 3,4-dihydro-4-oxo-3-[[5-(trifluoromethyl)-214C benzothiazolyl]methyl]-1-phthalazineacetic acid

✍ Scribed by Banavara L. Mylari; William J. Zembrowski

Publisher
John Wiley and Sons
Year
1991
Tongue
French
Weight
207 KB
Volume
29
Category
Article
ISSN
0022-2135

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✦ Synopsis

Synthesis of the title compound, C14 labeled CP-73,850 (zopolrestat), was accomplished by condensation of 1-phthalazineacetic acid, 3-14C cyanomethyl-3,4-dihydr0-4-0~0-, ethyl ester with 3-amino-4-mercapto-benzotrifluoride, followed by base hydrolysis of the resultant product, 1-phthalazineacetic acid, 3,4-dihydro-4-oxo-3-([5- trifluoromethyl)-2-benzothiazolyl]14C methyl]-3.4-di hydro-4-oxo-, ethyl ester.

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