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ChemInform Abstract: Synthesis and Biological Evaluation of [2′-Oxo-2,3-dihydro-3′H-spiro[chromene-4,5′- [1,3]oxazolidin]-3′yl]acetic Acid Derivatives as Aldose Reductase Inhibitors.

✍ Scribed by Simona Rapposelli; Frederico Da Settimo; Maria Digiacomo; Concettina La Motta; Annalina Lapucci; Stefania Sartini; Michael Vanni

Publisher: John Wiley and Sons
Year: 2011
Weight: 62 KB
Volume: 42
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.201141131

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✦ Synopsis

Abstract

A series of the title spirocyclic benzopyran derivatives (XI) (12 examples) is synthesized, which all prove to be selective inhibitors of aldose reductase (ARL2).

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ChemInform Abstract: Synthesis of 2-(2-D

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ChemInform Abstract: Cytotoxic Activity of 3-(5-Phenyl-3H-[1,2,4]dithiazol-3-yl)chromen-4-ones and 4-Oxo-4H-chromene-3-carbothioic Acid N-Phenylamides.

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ChemInform Abstract: Synthesis of 5-[(In

ChemInform Abstract: Synthesis of 5-[(Indol-2-on-3-yl)methyl]-2,2-dimethyl-1,3-dioxane-4,6-diones and Spirocyclopropyloxindole Derivatives. Potential Aldose Reductase Inhibitors.

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Synthesis of 5-[(Indol-2-on-3-yl)methyl]-2,2-dimethyl-1,3-dioxane-4,6diones and Spirocyclopropyloxindole Derivatives. Potential Aldose Reductase Inhibitors. -Indoles (I) are transformed into indolyl derivatives (IV) following a literature process. Subsequent reaction with 1 equiv. of NBS generates