Synthesis of a versatile purification handle for use with Boc chemistry solid phase peptide synthesis
β Scribed by Lynne E. Canne; Rachel L. Winston; Stephen B.H. Ken
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- French
- Weight
- 240 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
The anchoring the first amino acid in Boc chemistry to a 4-(3-hydroxy-4methylpentyl)phenylacetic acid linker is described and compared to the conventional Pam resin. The peptidyl-4-(4-methyl-3-pentoxy)phenylacetamide linkage is slightly more stable to TFA than the Pam linker but in contrast to the P
The terminating agent was used to block any N-terminal amino groups which had not reacted in the coupling steps. Blake and Li2 also employed this procedure to assure complete acylation of the N-terminal amino group in the solid-phase synthesis of a heptapeptide. They reported that the acetylation p