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A comparative study of terminating agents for use in solid-phase peptide synthesis

✍ Scribed by Lowell D. Markley; Linneaus C. Dorman

Publisher
Elsevier Science
Year
1970
Tongue
French
Weight
173 KB
Volume
11
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

✦ Synopsis

The terminating agent was used to block any N-terminal amino groups which had not reacted in the coupling steps. Blake and Li2 also employed this procedure to assure complete acylation of the N-terminal amino group in the solid-phase synthesis of a heptapeptide.

They reported that the acetylation procedure consumed 9% of the free amine during the reaction time employed. Recently Wielandj reported the use of 3-nitrophthalic anhydride as a terminating agent.

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