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A new preparation of 4-(BOC-aminoacyloxymethyl)phenylacetic acids for solid-phase peptide synthesis

✍ Scribed by Serge Plaue; Denis Heissler


Publisher
Elsevier Science
Year
1987
Tongue
French
Weight
158 KB
Volume
28
Category
Article
ISSN
0040-4039

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4-(3-Hydroxy-4-methylpentyl)phenylacetic
✍ Katri Rosenthal; Mikael Erlandsson; Anders UndΓ©n πŸ“‚ Article πŸ“… 1999 πŸ› Elsevier Science 🌐 French βš– 200 KB

The anchoring the first amino acid in Boc chemistry to a 4-(3-hydroxy-4methylpentyl)phenylacetic acid linker is described and compared to the conventional Pam resin. The peptidyl-4-(4-methyl-3-pentoxy)phenylacetamide linkage is slightly more stable to TFA than the Pam linker but in contrast to the P