Synthesis and application of N-Boc-L-2-amino-4-(diethylphosphono)-4,4-difluorobutanoic acid for solid-phase synthesis of nonhydrolyzable phosphoserine peptide analogues
✍ Scribed by Akira Otaka; Kengo Miyoshi; Terrence R Burke Jr.; Peter P Roller; Hideki Kubota; Hirokazu Tamamura; Nobutaka Fujii
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- French
- Weight
- 216 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0040-4039
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## Abstract The title compounds have been prepared by a simple and economical procedure from the corresponding Bocprotected α‐benzyl esters and [^15^N]ammonia with N,N′‐carbonyldiimidazole as coupling agent. Catalytic hydrogenolysis furnished both labelled products in high overall yields suitable f
## Abstract The synthesis of two analogues of the __N__‐terminal tetradecapeptide of ribonuclease A (RNase S‐peptide 1‐14), in which the active site histidine‐12 residue is replaced by β‐(2‐pyridyl)‐__L__‐alanine and β‐(4‐pyridyl)‐__L__‐alanine, has been accomplished by the solid‐phase method. The