Synthesis of a pyrazole prostacyclin
β Scribed by M. Suzuki; S. Sugiura; R. Noyori
- Publisher
- Elsevier Science
- Year
- 1982
- Tongue
- French
- Weight
- 250 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0040-4039
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Thiazole analogs of prostacyclln were prepared from the cyclopentene (g), itself. obtained z a novel opening of 3,4-epoxycyclopentene with the llthloallylthloether (4). Widespread interest ln the synthesis and biological properties of prostacyclin (PGQ, (1))3 has followed th; discovery that prosta
Starting from Y-lactone intermediates, a novel method for the synthesis of the 5,6-dihydro-4H-cyclopenta[blfuran system has been developed which was utilized to prepare furanoprostacyclin derivatives. Because of the inherent instability of prostacyclin towards hydrolytic conditions 2 and its rapid d
## Abstract The synthesis of [11Ξ²β^3^H]prostacyclin and [11Ξ²β^3^H]6βoxoβprostaglandin F~1Ξ±~ has been described. The strategy involved borotritide reduction of prostaglandin D~2~, followed by cyclic iodoether formation. Adenylate cyclase activation in a neuronal somatic cell hybrid and GCβMS were us