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Synthesis Of [11β-3H]prostacyclin

✍ Scribed by Ian A. Blair; Christopher N. Hensby; John Macdermot

Publisher
John Wiley and Sons
Year
1981
Tongue
French
Weight
292 KB
Volume
18
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The synthesis of [11β‐^3^H]prostacyclin and [11β‐^3^H]6‐oxo‐prostaglandin F~1α~ has been described. The strategy involved borotritide reduction of prostaglandin D~2~, followed by cyclic iodoether formation. Adenylate cyclase activation in a neuronal somatic cell hybrid and GC‐MS were used for the analysis of the target compounds. The ready acid catalysed ketal formation of [11β‐^3^H]6‐oxo‐prostaglandin F~1α~ is noted.

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