Synthesis of a new family of protected 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid derivatives with thioctic acid pending arms
✍ Scribed by de la Reberdière, Arnaud; Lachaud, Fabien; Chuburu, Françoise; Cadiou, Cyril; Lemercier, Gilles
- Book ID
- 123329265
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- French
- Weight
- 267 KB
- Volume
- 53
- Category
- Article
- ISSN
- 0040-4039
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## Abstract True tracer radiolabeling, purification, and analysis of a gadolinium complex of HP‐DO3A (10‐(2‐hydroxy‐propyl)‐1,4,7,10‐tetraazacyclo dodecane‐1,4,7‐triacetic acid) was achieved by the reaction of carrier‐added ^153^GdCl~3~ and excess free ligand. Two analytical methods (ITLC and HPLC)
Gd(III) complexes of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid bearing two and four hydroxymethyl moieties on the cyclen ring were prepared to be studied as low toxicity MRI contrast agents. The key intermediates in the syntheses of the two ligands are the corresponding bis and tetras