Improved Synthesis of 10-(2-Alkylamino-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triacetic Acid Derivatives Bearing Acid-Sensitive Linkers
✍ Scribed by Jagadish, Bhumasamudram; Ozumerzifon, Tarik J.; Roberts, Sue A.; Hall, Gabriel B.; Mash, Eugene A.; Raghunand, Natarajan
- Book ID
- 121382194
- Publisher
- Taylor and Francis Group
- Year
- 2013
- Tongue
- English
- Weight
- 394 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0039-7911
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## Abstract True tracer radiolabeling, purification, and analysis of a gadolinium complex of HP‐DO3A (10‐(2‐hydroxy‐propyl)‐1,4,7,10‐tetraazacyclo dodecane‐1,4,7‐triacetic acid) was achieved by the reaction of carrier‐added ^153^GdCl~3~ and excess free ligand. Two analytical methods (ITLC and HPLC)
## Abstract Four new ligands for lanthanide ions based on the H~3~do3a (=1,4,7,10‐tetraazacyclododecane‐1,4,7‐triacetic acid) structure and bearing one __N__‐sulfonylacetamide arm were synthesized, __i.e.__, H~4~dota‐NHSO~2~R=10‐{2‐[(R)sulfonylamino]‐2‐oxoethyl}‐1,4,7,10‐tetraazacyclododecane‐1,4,7
Gd(III) complexes of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid bearing two and four hydroxymethyl moieties on the cyclen ring were prepared to be studied as low toxicity MRI contrast agents. The key intermediates in the syntheses of the two ligands are the corresponding bis and tetras