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A New Synthesis of Cyclen (1,4,7,10-Tetraazacyclododecane)

โœ Scribed by Weisman, Gary R.; Reed, David P.


Book ID
121363156
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
27 KB
Volume
62
Category
Article
ISSN
0022-3263

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๐Ÿ“œ SIMILAR VOLUMES


Expeditious N-monoalkylation of 1,4,7,10
โœ Vincenzo Boldrini; Giovanni B Giovenzana; Roberto Pagliarin; Giovanni Palmisano; ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 109 KB

The reaction of cyclen 1 with chloral hydrate aorded exclusively 1,4,7-triformylcyclen 2 in high yield; the triprotected macrocycle was easily alkylated with various electrophiles in good to excellent yields. The alkaline removal of the formyl groups provided a selective entry into N-monosubstituted