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Synthesis of a labeled inhibitor of HIV-1 attachment: 1-(4-benzoylpiperazin-1-yl)-2-(4,7-dimethoxy-1H-pyrrolo[2,3-c]pyridinyl-3-yl-[U-14C]ethane-1,2-dione, BMS-488043-14C

✍ Scribed by I. Victor Ekhato; J. Kent Rinehart

Publisher
John Wiley and Sons
Year
2010
Tongue
French
Weight
118 KB
Volume
54
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

BMS‐488043 is a potent inhibitor of the interaction between HIV‐1 gp120 and the host cell receptor CD4. We prepared the carbon‐14‐labeled version to support preclinical studies of the compound. It was prepared from ethyl [U‐^14^C]oxalyl chloride by a sequence using Friedel–Crafts acylation reaction. The overall radiochemical yield was 82% with a purity of >99.9%. Copyright © 2010 John Wiley & Sons, Ltd.

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