A new synthesis of the vernolepin a-ring
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Robin D. Clark; Clayton H. Heathcock
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Article
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1974
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Elsevier Science
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French
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The sesquiterpene bis-lactone vernolepin (1) shows significant cytotoxic and anti-tumor activity. 1 Grieco has recently outlined a rather lengthy synthesis of 2, which constitutes a model for rings A and B of vernolepin. 2 In connection with our own interest in this problem, we have devised a much