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Synthesis of a cytotoxic vernolepin prototype. Ozonization of silyloxyalkenes

โœ Scribed by Clark, Robin D.; Heathcock, Clayton H.


Book ID
118019252
Publisher
American Chemical Society
Year
1976
Tongue
English
Weight
999 KB
Volume
41
Category
Article
ISSN
0022-3263

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๐Ÿ“œ SIMILAR VOLUMES


A new synthesis of the vernolepin a-ring
โœ Robin D. Clark; Clayton H. Heathcock ๐Ÿ“‚ Article ๐Ÿ“… 1974 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 120 KB

The sesquiterpene bis-lactone vernolepin (1) shows significant cytotoxic and anti-tumor activity. 1 Grieco has recently outlined a rather lengthy synthesis of 2, which constitutes a model for rings A and B of vernolepin. 2 In connection with our own interest in this problem, we have devised a much