Synthesis of a cancer growth-inhibiting diterpene—Stereoselective formal synthesis of (+)-aphidicolin
✍ Scribed by Masahiro Toyota; Youichi Nishikawa; Keiichiro Fukumoto
- Book ID
- 107857913
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- French
- Weight
- 930 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0040-4020
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## Abstract A novel formal synthesis of fumagillol, a direct precursor of the antiangiogenic sesquiterpene fumagillin, is described. The main features of the synthesis are a stereoselective Claisen−Ireland rearrangement, a ring‐closing metathesis, a chemo‐ and stereoselective dihydroxylation, and a