Aphidicolin synthesis (II)—an expeditiou
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Masahiro Toyota; Youichi Nishikawa; Keiichiro Fukumoto
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Article
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1994
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Elsevier Science
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French
⚖ 941 KB
An expeditious and efftcient formal total synthesis of an antiviral and antitumor tetracyclic diterpene aphidicolin (1) has been achieved. An intramoleculat Heck reaction (74) and an intramolecular Diels-Aldex reaction (4+3) were utilii for the key steps of the sequence.