✦ LIBER ✦

A formal total synthesis of (−)-brevisamide

✍ Scribed by Amos B. Smith III; Noriki Kutsumura; Justin Potuzak

Publisher: Elsevier Science
Year: 2011
Tongue: French
Weight: 444 KB
Volume: 52
Category: Article
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2010.11.013

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✦ Synopsis

A formal total synthesis of (-)-brevisamide has been achieved. The synthetic approach highlights a chemoselective asymmetric dihydroxylation and a one-pot Fraser-Reid epoxidation/PMB protection reaction sequence.

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