## Abstract A novel formal synthesis of fumagillol, a direct precursor of the antiangiogenic sesquiterpene fumagillin, is described. The main features of the synthesis are a stereoselective ClaisenβIreland rearrangement, a ringβclosing metathesis, a chemoβ and stereoselective dihydroxylation, and a
A Stereoselective Formal Synthesis of (-)-Fumagillol.
β Scribed by Olivier Bedel; Arnaud Haudrechy; Yves Langlois
- Publisher
- John Wiley and Sons
- Year
- 2005
- Weight
- 9 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0931-7597
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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A 13-step synthesis of (Β±)-fumagillol (1), the direct precursor of the potent angiogenesis inhibitors TNP-470 and fumagillin, from crotonaldehyde, diethylamine, and acrolein (see the scheme) has been achieved. The synthesis features a remarkable hetero-Claisen rearrangement. Small-molecule inhibitor
## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.