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ChemInform Abstract: A Concise Synthesis of Fumagillol.

✍ Scribed by David A. Vosburg; Sven Weiler; Erik J. Sorensen

Publisher
John Wiley and Sons
Year
2010
Weight
24 KB
Volume
30
Category
Article
ISSN
0931-7597

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A Concise Synthesis of Fumagillol
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✍ David A. Vosburg; Sven Weiler; Erik J. Sorensen πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 100 KB πŸ‘ 2 views

A 13-step synthesis of (Β±)-fumagillol (1), the direct precursor of the potent angiogenesis inhibitors TNP-470 and fumagillin, from crotonaldehyde, diethylamine, and acrolein (see the scheme) has been achieved. The synthesis features a remarkable hetero-Claisen rearrangement. Small-molecule inhibitor

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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a β€œFull Text” option. The original article is trackable v