ChemInform Abstract: A Concise Synthesis of Fumagillol.
β Scribed by Martin Hutchings; David Moffat; Nigel S. Simpkins
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 28 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0931-7597
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π SIMILAR VOLUMES
A 13-step synthesis of (Β±)-fumagillol (1), the direct precursor of the potent angiogenesis inhibitors TNP-470 and fumagillin, from crotonaldehyde, diethylamine, and acrolein (see the scheme) has been achieved. The synthesis features a remarkable hetero-Claisen rearrangement. Small-molecule inhibitor
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