𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of a Bisubstrate-Type Inhibitor of N-Acetylglucosaminyltransferases

✍ Scribed by Shinya Hanashima; Shino Manabe; Kei-ichiro Inamori; Naoyuki Taniguchi; Yukishige Ito

Book ID
101560866
Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
210 KB
Volume
43
Category
Article
ISSN
0044-8249

No coin nor oath required. For personal study only.

πŸ“œ SIMILAR VOLUMES

Bisubstrate-type inhibitor of sialyltran
Bisubstrate-type inhibitor of sialyltransferases
✍ Hiroshi Hinou; Xue-Long Sun; Yukishige Ito πŸ“‚ Article πŸ“… 2002 πŸ› Elsevier Science 🌐 French βš– 141 KB

A convergent strategy for the construction of bisubstrate-type sialyltransferase inhibitor (1) was developed. It consists of consecutive coupling of three components (N-acetyllactosamine, sialic acid, and CMP), followed by oxidation and deprotection. As expected, compound 1 showed potent inhibitory

Synthesis of Bisubstrate Inhibitors of P
Synthesis of Bisubstrate Inhibitors of Porphobilinogen Synthase from Pseudomonas aeruginosa
✍ Sabine Gacond; Frederic FrΓ¨re; Merle Nentwich; Jean-Philippe Faurite; Nicole Fra πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 English βš– 160 KB

## Abstract Porphobilinogen synthase (PBGS) synthesizes porphobilinogen **2** (PBG), the common precursor of all natural tetrapyrroles, through an asymmetric condensation of two molecules of 5‐aminolevulinic acid **1** (ALA). Symmetrically linked dimers **7**–**11** derived from levulinic acid **3*