Bisubstrate-type inhibitor of sialyltran
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Hiroshi Hinou; Xue-Long Sun; Yukishige Ito
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Article
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2002
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Elsevier Science
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French
โ 141 KB
A convergent strategy for the construction of bisubstrate-type sialyltransferase inhibitor (1) was developed. It consists of consecutive coupling of three components (N-acetyllactosamine, sialic acid, and CMP), followed by oxidation and deprotection. As expected, compound 1 showed potent inhibitory