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Systematic Syntheses and Inhibitory Activities of Bisubstrate-Type Inhibitors of Sialyltransferases

โœ Scribed by Hinou, Hiroshi; Sun, Xue-Long; Ito, Yukishige


Book ID
121413484
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
302 KB
Volume
68
Category
Article
ISSN
0022-3263

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Bisubstrate-type inhibitor of sialyltran
โœ Hiroshi Hinou; Xue-Long Sun; Yukishige Ito ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 141 KB

A convergent strategy for the construction of bisubstrate-type sialyltransferase inhibitor (1) was developed. It consists of consecutive coupling of three components (N-acetyllactosamine, sialic acid, and CMP), followed by oxidation and deprotection. As expected, compound 1 showed potent inhibitory