Bisubstrate-type inhibitor of sialyltransferases

✍ Scribed by Hiroshi Hinou; Xue-Long Sun; Yukishige Ito

• Book ID: 104252429
• Publisher: Elsevier Science
• Year: 2002
• Tongue: French
• Weight: 141 KB
• Volume: 43
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(02)02272-4

✦ Synopsis

A convergent strategy for the construction of bisubstrate-type sialyltransferase inhibitor (1) was developed. It consists of consecutive coupling of three components (N-acetyllactosamine, sialic acid, and CMP), followed by oxidation and deprotection. As expected, compound 1 showed potent inhibitory activities toward both 2,3-(N)-and 2,6-(N)-sialyltransferase.