## Abstract ^13^C labelled (1,2 and 1,12) and perdeuterated derivatives of 2‐phenyl cyclododecanones, as precursors for labelled triplet flexible biradicals to probe magnetic isotope effects at the radical centers on the triplet decay dynamics, were synthesized. Isotopomers of 2‐phenylcyclododecano
Synthesis of a [13CO2H]-labelled bilirubin
✍ Scribed by Daniel F. Nogales; David A. Lightner
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- French
- Weight
- 467 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0022-2135
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✦ Synopsis
Abstract
Bis‐[^13^CO~2~H]‐mesobilirubin‐XIIIα was synthesized in 11% overall yield in 10 steps from 99% enriched K^13^CN. The synthetic methods are adapted to a scale of a few grams to a few milligrams.
📜 SIMILAR VOLUMES
The incorporation of carbon-13 and deuterium i n the t,2,3-thiadiaxoZe framework i s described.
## Abstract Efficient methods for synthesising L‐[methy‐ ^13^C]methionine from [^13^C]iodomethane and L‐methionine, and L‐[3,4‐^13^C~2~] methionine from [^13^C~2~]ethene, are described; the preparation of [3,3‐^2^H~2~]methionine and [2,3,3‐^2^H~3~]methionine from methionine by an exchange method is
## Conclusions The synthesis of AZD4619 included 14 steps with an overall yield of 13%. To reach the requirements of an increase in molecular weight by at least nine, both 13 C and 2 H had to be incorporated. According to our previous experiences the loss of deuterium in acidic positions necessita
## Abstract Sunitinib (Sutent^®^, Pfizer) was approved in 2006 for the treatment of gastrointestinal and renal cancer. Isotope‐labelled derivatives have already been prepared for PET and ADME radiography. The preparation of ^13^C‐ and ^2^H‐labelled internal standards of sunitinib (SU11248) and its