Glycosidation of the lactose derivative 4 with [1-13 C]-sialyl sialic acid gave the trisaccharide 5 which was transformed into [1c-13 C]-GM 3 ([1c-13 C]-1). xanthate 3, prepared from enzymatically obtained [1-13 C]-FULL PAPER Scheme 2 Reagents and conditions: (a) PST, AgOTf, CH 3 CN/CH 2 Cl 2 , Ϫ70°
Synthesis of methionines specifically labelled with 2H or 13C
✍ Scribed by David C. Billington; Bernard T. Golding; Michael J. Kebbell; Ishaq K. Nassereddin
- Publisher
- John Wiley and Sons
- Year
- 1981
- Tongue
- French
- Weight
- 478 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0022-2135
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
Efficient methods for synthesising L‐[methy‐ ^13^C]methionine from [^13^C]iodomethane and L‐methionine, and L‐[3,4‐^13^C~2~] methionine from [^13^C~2~]ethene, are described; the preparation of [3,3‐^2^H~2~]methionine and [2,3,3‐^2^H~3~]methionine from methionine by an exchange method is detailed.
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