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Synthesis of 2H- and 13C-labelled sunitinib and its primary metabolite

✍ Scribed by Paul W. Elsinghorst; Michael Gütschow

Publisher
John Wiley and Sons
Year
2009
Tongue
French
Weight
210 KB
Volume
52
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Sunitinib (Sutent^®^, Pfizer) was approved in 2006 for the treatment of gastrointestinal and renal cancer. Isotope‐labelled derivatives have already been prepared for PET and ADME radiography. The preparation of ^13^C‐ and ^2^H‐labelled internal standards of sunitinib (SU11248) and its primary metabolite (SU12662) for LC‐MS analysis of human blood samples is presented. Copyright © 2009 John Wiley & Sons, Ltd.

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