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Synthesis of JTT-501 and its metabolite JTP-20604 labelled with 13C

✍ Scribed by A. Pignatti; D. Giribone; C. Felicini; E. Fontana

Publisher
John Wiley and Sons
Year
2003
Tongue
French
Weight
115 KB
Volume
46
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

JTT‐501 specifically labelled with ^13^C was obtained via a four‐step synthesis at an isotopic enrichment level of 99% and in 14% overall chemical yield starting from 4‐hydroxy‐[ring‐U‐^13^C~6~]benzaldehyde (3). The hydrogenation of [^13^C~6~]JTT‐501 over Pd/C gave [^13^C~6~]JTP‐20604 in 90% chemical yield. Copyright © 2003 John Wiley & Sons, Ltd.

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